Abstract
The synthesis and structure-activity relationships of HIV protease inhibitors derived from carbohydrate alditols are discussed. We disclose a new series of 1,2,5,6-tetra-O-alkyl-D-mannitol exhibiting sub-micromolar activity against HIV-protease. This series of inhibitors are non-nitrogen containing HIV-protease inhibitors and they are readily prepared in a few chemical steps from inexpensive commercially available starting materials.
MeSH terms
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Benzyl Compounds / chemical synthesis
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Benzyl Compounds / chemistry*
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Benzyl Compounds / pharmacology*
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HIV Protease Inhibitors / chemical synthesis
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HIV Protease Inhibitors / chemistry*
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HIV Protease Inhibitors / pharmacology*
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Mannitol / analogs & derivatives*
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Mannitol / chemical synthesis
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Mannitol / chemistry
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Mannitol / pharmacology
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Structure-Activity Relationship
Substances
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Benzyl Compounds
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HIV Protease Inhibitors
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Mannitol