Abstract
Syntheses and physicochemical properties of 2,4,6-tri-, 2,3,4,6-tetra-, or 2,3,4,5,6-pentasubstituted 1-(2-sulfonamido-1,3,4-thiadiazol-5-yl)pyridinium perchlorates are presented. The new compounds, putative inhibitors of membrane-bound carbonic anhydrase, were tested for inhibitory action on the bovine red cell enzyme.
MeSH terms
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Carbonic Anhydrase Inhibitors / chemical synthesis*
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Carbonic Anhydrase Inhibitors / pharmacology
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Isoenzymes
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Magnetic Resonance Spectroscopy
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Pyridinium Compounds / chemical synthesis*
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Thiadiazoles / chemical synthesis*
Substances
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Carbonic Anhydrase Inhibitors
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Isoenzymes
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Pyridinium Compounds
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Thiadiazoles