Abstract
D-Glucose 3- and 6-[sodium 2-(perfluoro-hexyl or -octyl)ethyl phosphates) have been synthesized by condensation of 1,2,3,4,-tetra-O-acetyl-beta-D-glucopyranose and 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose with 2-(perfluoroalkyl)ethylphosphoroditriazolides followed by O-deacetylation or deacetalation. The structures of the compounds were established on the basis of 1H-, 19F-, 31P-, and 13C-NMR data. These salts display strong surface activities and appear to have good biocompatibility.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / chemistry
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Blood Substitutes / chemical synthesis*
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Blood Substitutes / chemistry
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Fluorocarbons / chemistry*
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Fluorocarbons / therapeutic use
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Glucose / analogs & derivatives*
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Glucose / chemistry*
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Glucose / therapeutic use
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Surface-Active Agents / chemical synthesis*
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Surface-Active Agents / chemistry
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Surface-Active Agents / therapeutic use
Substances
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Biocompatible Materials
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Blood Substitutes
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Fluorocarbons
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Surface-Active Agents
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fluosol
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Glucose