Prolonged shelf stability and biocompatibility of a concentrated injectable fluorocarbon emulsion

Biomater Artif Cells Immobilization Biotechnol. 1992;20(2-4):1059-61. doi: 10.3109/10731199209119763.

Abstract

A four-year-old 100% w/v concentrated emulsion of perfluorooctylbromide (PFOB, perflubron) stored at 5 degrees C, when submitted to the close-to-total exchange-perfusion test in conscious rats (Hct 3-5%) still resulted in 75% survival. Particle size and size distribution, viscosity, pH were still in the acceptable range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Substitutes* / administration & dosage
  • Drug Stability
  • Emulsions
  • Exchange Transfusion, Whole Blood
  • Fluorocarbons* / administration & dosage
  • Hydrocarbons, Brominated
  • Materials Testing
  • Rats
  • Time Factors

Substances

  • Blood Substitutes
  • Emulsions
  • Fluorocarbons
  • Hydrocarbons, Brominated
  • perflubron