The results of mass prophylactic screening of the population for tuberculosis in the south of the Aral sea costal region have been generalized with consideration of its geographic and sanitary--epidemiologic conditions. A mixed model of comprehensive prophylactic screenings was used for the first time with integration, for the first time, of the traditional (team) and field-work methods. The obtained results proved the efficiency of this approach: during one year a total of 1,217,400 subjects or 80% of the relevant population were involved in the prophylactic screening for the first time in one region. As a result, the epidemiologic situation related to tuberculosis was revealed and a complex of the therapeutic and health-improvement measures accomplished. The proposed measures have been tested and made the basis of a section in a complex program "Health of the population of the Aral sea costal region up to the 2000th year" which is recently being introduced in other regions of the republic.