Structure-activity relationship of new 10-13 membered oxygen-nitrogen heterocyclic systems containing two aromatic rings

K Walczyński; R Glinka; A Stepień; T Olszak; P Sabatino

Structure-activity relationship of new 10-13 membered oxygen-nitrogen heterocyclic systems containing two aromatic rings

Pharmazie. 1992 Jun;47(6):409-11.

Authors

K Walczyński¹, R Glinka, A Stepień, T Olszak, P Sabatino

Affiliation

¹ Department of Technology and Chemistry of Drugs, Medical Akademy of Lódź, Poland.

PMID: 1357679

Abstract

The synthesis and biological activity of new 10-13 membered oxygen-nitrogen heterocyclic systems condensed with two aromatic rings is reported. The structure-activity relationship of these new compounds in X-ray investigation has been studied. Pharmacological investigations have shown that the compounds exhibit weak neuroleptic activity.

MeSH terms

Animals
Antipsychotic Agents / chemical synthesis*
Antipsychotic Agents / pharmacology
Behavior, Animal / drug effects
Cerebral Cortex / drug effects
Cerebral Cortex / metabolism
Dopamine D2 Receptor Antagonists
Heterocyclic Compounds / chemical synthesis*
Heterocyclic Compounds / pharmacology
In Vitro Techniques
Male
Rats
Receptors, Dopamine D1 / antagonists & inhibitors
Receptors, Muscarinic / drug effects
Receptors, Muscarinic / metabolism
Structure-Activity Relationship
X-Ray Diffraction

Substances

Antipsychotic Agents
Dopamine D2 Receptor Antagonists
Heterocyclic Compounds
Receptors, Dopamine D1
Receptors, Muscarinic