Abstract
The role of D1 receptors in motor control is poorly understood. In parkinsonian squirrel monkeys, the full D1 agonist C-APB (SKF 82958; 0.1-0.4 mg/kg s.c.) caused weak stimulation of locomotor activity. However, the motor stimulant effects of the D2 agonist (+)-PHNO (0.001 mg/kg s.c.) were not potentiated by C-APB (0.3 mg/kg). Differences between these observations and expectations from experiments using rodents are discussed.
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Animals
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Antiparkinson Agents / pharmacology*
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Benzazepines*
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Dopamine Agents / pharmacology*
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Drug Synergism
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Male
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Motor Activity / drug effects
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Parkinson Disease, Secondary / chemically induced
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Parkinson Disease, Secondary / physiopathology
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Receptors, Dopamine / physiology*
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Saimiri
Substances
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Antiparkinson Agents
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Benzazepines
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Dopamine Agents
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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SK&F 82958
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine