Weak antiparkinsonian activity of the D1 agonist C-APB (SKF 82958) and lack of synergism with a D2 agonist in primates

Clin Neuropharmacol. 1992 Aug;15(4):307-9. doi: 10.1097/00002826-199208000-00005.

Abstract

The role of D1 receptors in motor control is poorly understood. In parkinsonian squirrel monkeys, the full D1 agonist C-APB (SKF 82958; 0.1-0.4 mg/kg s.c.) caused weak stimulation of locomotor activity. However, the motor stimulant effects of the D2 agonist (+)-PHNO (0.001 mg/kg s.c.) were not potentiated by C-APB (0.3 mg/kg). Differences between these observations and expectations from experiments using rodents are discussed.

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Antiparkinson Agents / pharmacology*
  • Benzazepines*
  • Dopamine Agents / pharmacology*
  • Drug Synergism
  • Male
  • Motor Activity / drug effects
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / physiopathology
  • Receptors, Dopamine / physiology*
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Saimiri

Substances

  • Antiparkinson Agents
  • Benzazepines
  • Dopamine Agents
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • SK&F 82958
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine