13-hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4 in vivo in rabbit skin

T L Buckley; M J Van de Velde; P A Henricks; F Engels; F P Nijkamp

doi:10.1016/0014-2999(92)90195-a

13-hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4 in vivo in rabbit skin

Eur J Pharmacol. 1992 Aug 6;218(2-3):369-72. doi: 10.1016/0014-2999(92)90195-a.

Authors

T L Buckley¹, M J Van de Velde, P A Henricks, F Engels, F P Nijkamp

Affiliation

¹ Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, Netherlands.

PMID: 1330604
DOI: 10.1016/0014-2999(92)90195-a

Abstract

Intradermal 13-hydroxyoctadecadienoic acid (13-HODE; 10(-11)-10(-9) mol/site) inhibited oedema formation induced by the neutrophil-dependent mediator leukotriene B4 (LTB4) in the presence of calcitonin gene-related peptide (CGRP; 10(-11) mol/site) in rabbit skin. In contrast, the responses to the direct acting mediators bradykinin and histamine were unaffected by 13-HODE. 13-HODE failed to induce oedema formation in rabbit skin when injected alone or in the presence of the potent vasodilator CGRP. These results present a novel interaction between 13-HODE and LTB4 that could have important implications in the pathogenesis of inflammation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analysis of Variance
Animals
Calcitonin Gene-Related Peptide / physiology
Edema / physiopathology
Edema / prevention & control*
Leukotriene B4 / antagonists & inhibitors*
Leukotriene B4 / physiology
Linoleic Acids / pharmacology*
Rabbits
Skin / drug effects*
Skin / physiopathology

Substances

Linoleic Acids
Leukotriene B4
13-hydroxy-9,11-octadecadienoic acid
Calcitonin Gene-Related Peptide