Negative inotropic and chronotropic activity of calcium channel ligands possessing a xanthone 1,4-dihydropyridine backbone

Arzneimittelforschung. 1992 Jun;42(6):797-801.

Abstract

A series of xanthone 1,4-dihydropyridine derivatives were prepared. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta, Thoracic / drug effects
  • Calcium Channels / drug effects*
  • Depression, Chemical
  • Dihydropyridines / pharmacology*
  • Female
  • Guinea Pigs
  • Heart Rate / drug effects*
  • In Vitro Techniques
  • Ligands
  • Male
  • Muscle Contraction / drug effects
  • Myocardial Contraction / drug effects*
  • Stimulation, Chemical
  • Xanthenes / pharmacology*

Substances

  • Calcium Channels
  • Dihydropyridines
  • Ligands
  • Xanthenes