Abstract
Four variants of merozoite surface protein 2 (MSP-2) of Plasmodium falciparum were used in serology to examine whether changes in repeat units affect its recognition by antibodies during infection with parasites of known MSP-2 types. The results indicate that variation in MSP-2 repeats may represent a mechanism for parasite immune evasion.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Amino Acid Sequence
-
Animals
-
Antibodies, Protozoan / immunology*
-
Antigens, Protozoan / genetics
-
Antigens, Protozoan / immunology*
-
Brazil
-
Enzyme-Linked Immunosorbent Assay
-
Humans
-
In Situ Hybridization
-
Malaria, Falciparum / immunology*
-
Male
-
Middle Aged
-
Molecular Sequence Data
-
Plasmodium falciparum / immunology*
-
Polymerase Chain Reaction
-
Protozoan Proteins / genetics
-
Protozoan Proteins / immunology*
-
Recombinant Proteins / genetics
-
Recombinant Proteins / immunology
Substances
-
Antibodies, Protozoan
-
Antigens, Protozoan
-
Protozoan Proteins
-
Recombinant Proteins
-
merozoite surface protein 2, Plasmodium