Abstract
Eukaryotes employ redundant mechanisms to limit the replication of genomic DNA to only once per cycle. These mechanisms prevent DNA re-replication by restricting the assembly of the pre-replication complex to the cell cycle stages of late mitosis and G1 phase so that the re-initiation of DNA replication cannot occur during S phase. Here we discuss the conserved yet divergent mechanisms of replication control employed in yeast and metazoan species, including a perspective on the newly uncovered role of the CUL-4 ubiquitin ligase as a central regulator of DNA replication in the nematode Caenorhabditis elegans.
MeSH terms
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Animals
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / metabolism*
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Cell Cycle / genetics
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Cell Cycle / physiology
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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DNA Replication / genetics
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DNA Replication / physiology*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Drosophila
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G1 Phase / genetics
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G1 Phase / physiology
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Ligases / genetics
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Ligases / metabolism*
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Minichromosome Maintenance Complex Component 2
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Mitosis / genetics
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Mitosis / physiology
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism*
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Origin Recognition Complex
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Replication Origin / genetics
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Replication Origin / physiology
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Saccharomyces cerevisiae Proteins*
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Saccharomycetales / genetics
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Saccharomycetales / metabolism
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Schizosaccharomyces / genetics
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Schizosaccharomyces / metabolism
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Schizosaccharomyces pombe Proteins
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Xenopus / genetics
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Xenopus / metabolism
Substances
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CDC6 protein, S cerevisiae
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Caenorhabditis elegans Proteins
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Cell Cycle Proteins
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Cul-4 protein, C elegans
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DNA-Binding Proteins
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Nuclear Proteins
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Origin Recognition Complex
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Saccharomyces cerevisiae Proteins
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Schizosaccharomyces pombe Proteins
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TAH11 protein, S cerevisiae
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cdt1 protein, S pombe
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Minichromosome Maintenance Complex Component 2
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Ligases