Abstract
New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / toxicity*
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Betulinic Acid
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Cell Line, Tumor
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Humans
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Pentacyclic Triterpenes
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Triterpenes / chemical synthesis*
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Triterpenes / toxicity*
Substances
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Antineoplastic Agents
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Pentacyclic Triterpenes
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Triterpenes
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Betulinic Acid