Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates

Org Biomol Chem. 2003 Aug 7;1(15):2630-47. doi: 10.1039/b303650m.

Abstract

The C7-C7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamides were synthesized and preliminary anti-cancer evaluation carried out by NCI against three types of cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Dimerization
  • Drug Evaluation, Preclinical
  • Drug Screening Assays, Antitumor*
  • Imidazoles / chemistry*
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Pyrroles / chemistry*
  • Pyrroles / pharmacology*

Substances

  • Antineoplastic Agents
  • Imidazoles
  • Indoles
  • Pyrroles
  • polyamide 1-(chloromethyl)-5-hydroxyl-1,2-dihydro--3H-benz(e)indole conjugate