Abstract
The C7-C7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamides were synthesized and preliminary anti-cancer evaluation carried out by NCI against three types of cancer cells.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology*
-
Dimerization
-
Drug Evaluation, Preclinical
-
Drug Screening Assays, Antitumor*
-
Imidazoles / chemistry*
-
Indoles / chemistry
-
Indoles / pharmacology*
-
Magnetic Resonance Spectroscopy
-
Mass Spectrometry
-
Pyrroles / chemistry*
-
Pyrroles / pharmacology*
Substances
-
Antineoplastic Agents
-
Imidazoles
-
Indoles
-
Pyrroles
-
polyamide 1-(chloromethyl)-5-hydroxyl-1,2-dihydro--3H-benz(e)indole conjugate