Isolation and identification of a cytotoxic principle from Chrysosplenium grayanum Maxim. (Saxifragaceae) and its antitumor activities

M Arisawa; H Bai; S Shimizu; S Koshimura; M Tanaka; T Sasaki; N Morita

doi:10.1248/cpb.40.3274

Isolation and identification of a cytotoxic principle from Chrysosplenium grayanum Maxim. (Saxifragaceae) and its antitumor activities

Chem Pharm Bull (Tokyo). 1992 Dec;40(12):3274-6. doi: 10.1248/cpb.40.3274.

Authors

M Arisawa¹, H Bai, S Shimizu, S Koshimura, M Tanaka, T Sasaki, N Morita

Affiliation

¹ Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Japan.

PMID: 1294331
DOI: 10.1248/cpb.40.3274

Abstract

A cytotoxic principle was newly isolated from Chrysosplenium grayanum Maxim. (Saxifragaceae) and identified as beta-peltoboykinolic acid (1) on the basis of spectral data. Cytotoxicity of compound 1 was tested against various human cancer cell lines in vitro, and antitumor effect of this compound was demonstrated on Meth.A mouse fibrosarcoma. The experiment of combined treatment with compound 1, mitomycin C, and OK-432 resulted in enhancing the antitumor effect against B16-BL6 mouse melanoma in C57BL/6 mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / toxicity
Cell Line
Cytotoxins / isolation & purification*
Cytotoxins / toxicity
Flavonoids / isolation & purification*
Flavonoids / toxicity
Growth Inhibitors / isolation & purification
Growth Inhibitors / toxicity
Humans
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Plants, Medicinal / chemistry*
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Cytotoxins
Flavonoids
Growth Inhibitors