[Research into simultaneous spectrophotometric determination of components in cough syrup by principal component regression method]

Guang Pu Xue Yu Guang Pu Fen Xi. 2002 Jun;22(3):427-9.
[Article in Chinese]

Abstract

Principal component regression (PCR) method is used to analyse five components: acetaminophen, p-aminophenol, caffeine, chlorphenamine maleate and guaifenesin. The basic principle and the analytical step of the approach are described in detail. The computer program of LHG is based on VB language. The experimental result shows that the PCR method has no systematical error as compared to classical method. The experimental result shows that the average recovery of each component is all in the range from 96.43% to 107.14%. Each component obtains satisfactory result without any pre-separation. The approach is simple, rapid and suitable for the computer-aid analysis.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetaminophen / analysis*
  • Aminophenols / analysis*
  • Analgesics, Non-Narcotic / analysis*
  • Caffeine / analysis*
  • Chlorpheniramine / analysis
  • Drug Combinations
  • Expectorants / analysis
  • Guaifenesin / analysis
  • Histamine H1 Antagonists / analysis
  • Sensitivity and Specificity
  • Spectrophotometry, Ultraviolet / methods

Substances

  • Aminophenols
  • Analgesics, Non-Narcotic
  • Drug Combinations
  • Expectorants
  • Histamine H1 Antagonists
  • Acetaminophen
  • Caffeine
  • Chlorpheniramine
  • Guaifenesin
  • 4-aminophenol