Abstract
Renieramycin J (1), a new tetrahydroisoquinoline alkaloid, has been isolated from a marine sponge Neopetrosia sp. as a potent cytotoxin that induced morphological changes in 3Y1 cells. Such changes are characteristic of RNA and/or protein synthesis inhibitors. The structure of 1 including the absolute stereochemistry was determined by spectroscopic and chemical methods.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Fibroblasts / drug effects
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Inhibitory Concentration 50
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Japan
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Rats
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Tetrahydroisoquinolines / chemistry
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Tetrahydroisoquinolines / isolation & purification*
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Tetrahydroisoquinolines / pharmacology
Substances
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Alkaloids
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Antineoplastic Agents
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Tetrahydroisoquinolines
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renieramycin J