Observation of high enantioselectivity for the gas phase hydrogenation of methyl pyruvate using supported Pt catalysts pre-modified with cinchonidine

Matthias von Arx; Nicholas Dummer; David J Willock; Stuart H Taylor; Richard P K Wells; Peter B Wells; Graham J Hutchings

Observation of high enantioselectivity for the gas phase hydrogenation of methyl pyruvate using supported Pt catalysts pre-modified with cinchonidine

Chem Commun (Camb). 2003 Aug 7:(15):1926-7.

Authors

Matthias von Arx¹, Nicholas Dummer, David J Willock, Stuart H Taylor, Richard P K Wells, Peter B Wells, Graham J Hutchings

Affiliation

¹ Department of Chemistry, Cardiff University, PO Box 912, Cardiff, UK CF10 3TB.

PMID: 12932036

Abstract

Pt supported on alpha-Al2O3, gamma-Al2O3 and SiO2 pre-modified with cinchonidine gives over 50% ee in the hydrogenation of methyl pyruvate to methyl lactate using gas phase reactants at 40 degrees C giving the first clear observation of high enantioselection at the gas/solid interface.