The effect of deprivation and the systemic inflammatory response on outcome following curative resection for colorectal cancer

D C McMillan; K Canna; C S McArdle

doi:10.1038/sj.bjc.6601156

The effect of deprivation and the systemic inflammatory response on outcome following curative resection for colorectal cancer

Br J Cancer. 2003 Aug 18;89(4):612-4. doi: 10.1038/sj.bjc.6601156.

Authors

D C McMillan¹, K Canna, C S McArdle

Affiliation

¹ University Department of Surgery, Royal Infirmary, Glasgow G31 ZER, UK. d.c.mcmillan@clinmed.gla.ac.uk

Abstract

The presence of a systemic inflammatory response predicted cancer-specific (HR 2.55, 95% CI 1.22-5.32, P<0.05) and overall survival (HR 2.12, 95% CI 1.17-3.87, P<0.05), independent of Dukes stage, in patients who had undergone apparently curative surgery for colorectal cancer (n=158). Deprivation predicted overall survival (HR 1.26, 95% CI 1.04-1.51, P<0.05) independent of Dukes stage.

MeSH terms

Aged
C-Reactive Protein / analysis
Colorectal Neoplasms / blood
Colorectal Neoplasms / mortality
Colorectal Neoplasms / surgery*
Female
Follow-Up Studies
Humans
Male
Neoplasm Staging
Poverty*
Prognosis
Survival Rate
Time Factors
Treatment Outcome

Substances

C-Reactive Protein