Abstract
Stilbene derivatives, which are resveratrol (3,4',5-trihydroxy-trans-stilbene) oligomers ranging from monomer to tetramer, isolated from Dipterocarpaceae plants were tested for their inhibitory effects against murine tyrosinase activity. The structure-activity relationships obtained in this study suggest that the double bond in the stilbene skeleton is critical for the inhibition, and also that molecular size is important for inhibitory potency.
MeSH terms
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Animals
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Cell Line, Tumor
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Ericales / chemistry*
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Mice
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Molecular Structure
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Monophenol Monooxygenase / antagonists & inhibitors*
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Monophenol Monooxygenase / metabolism
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Pyrones / chemistry
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Pyrones / pharmacology
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Resveratrol
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Stilbenes / chemistry
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Stilbenes / pharmacology*
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Pyrones
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Stilbenes
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kojic acid
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Monophenol Monooxygenase
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Resveratrol