Multinucleation of the sodC-deficient Dictyostelium discoideum

Biol Pharm Bull. 2003 Aug;26(8):1174-7. doi: 10.1248/bpb.26.1174.

Abstract

The cellular slime mold Dictyostelium discoideum expresses three genes (sodA, sodB and sodC) encoding the extracellular Cu/Zn superoxide dismutases. Following H(2)O(2) treatment, the expression of sodA and sodB increased while that of sodC decreased. The sodC null strain formed multinucleate cells in a shaking culture. These results suggest that sodC plays a unique role in Dictyostelium discoideum.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Dictyostelium / cytology
  • Dictyostelium / genetics*
  • Dictyostelium / metabolism*
  • Escherichia coli Proteins*
  • Genes, Protozoan* / drug effects
  • Giant Cells / cytology
  • Giant Cells / drug effects
  • Giant Cells / enzymology*
  • Hydrogen Peroxide / pharmacology
  • Molecular Sequence Data
  • Mutagenesis, Insertional
  • Sequence Analysis
  • Superoxide Dismutase / biosynthesis
  • Superoxide Dismutase / deficiency*
  • Superoxide Dismutase / genetics*

Substances

  • Escherichia coli Proteins
  • Hydrogen Peroxide
  • Superoxide Dismutase
  • sodC protein, E coli