A male patient with a bi-phasic Guillain-Barré syndrome is presented in the paper. Initially a paralysis of his left lower extremity was observed, with hypotonia and removal of deep reflexes, followed by a flaccid paralysis of the remaining extremities. This syndrome had been preceded by a Herpes zoster infection producing symptoms in the left shank and foot. The paresis of his left lower extremity had been increasing during the week before his admission, while the paralysis of the other extremities occurred not earlier than by the end of the second week of his hospitalization. The diagnosis of the Guillain-Barré syndrome was based on the clinical course of the disease, and results of EMG examination and of general laboratory tests of his cerebrospinal fluid.