Arrhythmogenic effects of endothelin-1 under conditions of NO-synthase blockade with L-NAME in NMRI mice

Bull Exp Biol Med. 2003 Apr;135(4):370-3. doi: 10.1023/a:1024616932288.

Abstract

Arrythmogenic effects of endothelin-1 were studied in NMRI mice under conditions of NO-synthase blockade with N omega-nitro-L-arginine methyl ester. Intravenous injection of endothelin-1 increased heart rate variability in awake mice. NO-synthase blockade potentiated the arrythmogenic effects of endothelin-1. In narcotized animals the arrythmogenic effect of endothelin-1 was not observed and was considerably weakened under conditions of NO-synthase blockade. Arrhythmia was paralleled by atrioventricular block and lengthening of the ST segment.

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / metabolism*
  • Blood Pressure / drug effects
  • Electrocardiography
  • Endothelin-1 / administration & dosage
  • Endothelin-1 / pharmacology*
  • Enzyme Inhibitors / pharmacology
  • Heart / drug effects*
  • Heart Rate / drug effects
  • Male
  • Mice
  • Mice, Inbred Strains
  • NG-Nitroarginine Methyl Ester / pharmacology*
  • Nitric Oxide Synthase / antagonists & inhibitors*
  • Nitric Oxide Synthase / metabolism

Substances

  • Endothelin-1
  • Enzyme Inhibitors
  • Nitric Oxide Synthase
  • NG-Nitroarginine Methyl Ester