DSLET and ACTH(4-10) increase mitotic activity of hepatocytes and suppress antibody production

Bull Exp Biol Med. 2003 May;135(5):428-9. doi: 10.1023/a:1024998805553.

Abstract

The mitotic index of hepatocytes remained unchanged after 10 intraperitoneal injections of DSLET and ACTH(4-10) in doses of 0.5, 1.5, and 5 microg/kg, but increased after injection of these substances in doses of 50 and 150 microg/kg. DSLET in doses of 5, 50, and 150 microg/kg decreased the number of antibody-producing cells in the spleen. ACTH(4-10) possessed immunosuppressive activity not only in these doses, but also in a dose of 1.5 microg/kg. As differentiated from mitotic activity of hepatocytes, the degree of immunosuppression increased with increasing the dose of test peptides.

MeSH terms

  • Adrenocorticotropic Hormone / pharmacology*
  • Analgesics / pharmacology
  • Animals
  • Antibodies / metabolism*
  • Dose-Response Relationship, Drug
  • Enkephalin, Leucine / analogs & derivatives*
  • Enkephalin, Leucine / pharmacology*
  • Hepatocytes* / drug effects
  • Hepatocytes* / physiology
  • Mice
  • Mice, Inbred CBA
  • Mitosis / physiology*
  • Nootropic Agents / pharmacology
  • Peptide Fragments / pharmacology*

Substances

  • Analgesics
  • Antibodies
  • Nootropic Agents
  • Peptide Fragments
  • Enkephalin, Leucine
  • enkephalin, Ser(2), Leu(5), Thr(6)-
  • Adrenocorticotropic Hormone
  • ACTH (4-10)