Combination of 5 Hz repetitive transcranial magnetic stimulation (rTMS) and tactile coactivation boosts tactile discrimination in humans

Neurosci Lett. 2003 Sep 11;348(2):105-8. doi: 10.1016/s0304-3940(03)00745-6.

Abstract

A combination of 5 Hz repetitive transcranial magnetic stimulation (rTMS) over the left primary somatosensory cortex together with tactile coactivation applied to the right index-finger representation (coac + rTMS) boosted tactile discrimination ability tested on the right index-finger. Applying coactivation alone caused a 0.25 mm lowering in tactile discrimination thresholds. In contrast, after coac + rTMS we found a significant further improvement of discrimination thresholds in comparison to the coactivation-induced perceptual changes alone. We demonstrate that the individual further improvement after coac + rTMS depended on the effectiveness of the coactivation protocol when applied alone. Subjects, who showed little gain in tactile performance after coactivation alone, showed the largest improvement after coac + rTMS implying that the combined application was selective for poor learners. The selective effects of coac + rTMS are discussed in respect to N-methyl-D-aspartate receptor activation.

MeSH terms

  • Adult
  • Discrimination Learning / physiology
  • Female
  • Humans
  • Long-Term Potentiation / physiology
  • Male
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Sensory Thresholds / physiology*
  • Somatosensory Cortex / physiology*
  • Synaptic Transmission / physiology
  • Touch / physiology*
  • Transcranial Magnetic Stimulation
  • Transcutaneous Electric Nerve Stimulation / methods

Substances

  • Receptors, N-Methyl-D-Aspartate