Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon

Bioorg Med Chem. 2003 Aug 15;11(17):3633-9. doi: 10.1016/s0968-0896(03)00349-3.

Abstract

The synthesis of carbocyclic and phosphonocarbocyclic analogues of ribavirin, an anti-HCV inhibitor, are described. Those compounds were evaluated against HCV but also against other important viruses in order to determine their spectrum of antiviral activity. Compounds 6 and 13 displayed a moderate IC(50) against HIV-1 of 43.8 and 37 microM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Hepacivirus / chemistry
  • Hepacivirus / drug effects*
  • Hepacivirus / genetics
  • Nucleosides / chemical synthesis
  • Replicon
  • Ribavirin / analogs & derivatives*
  • Ribavirin / chemical synthesis
  • Ribavirin / pharmacology

Substances

  • Antiviral Agents
  • Nucleosides
  • Ribavirin