[Association of a polymorphic marker C825T of the beta(3) subunit of G-protein with myocardial hypertrophy in patients with hypertensive disease]

E V Shliakhto; E I Shwarts; L A Sokolova; Iu B Nefedova; A V Zhukova; T A Vinnik; I A Tolstova; O G Rudomanov; A O Konradi

[Association of a polymorphic marker C825T of the beta(3) subunit of G-protein with myocardial hypertrophy in patients with hypertensive disease]

Kardiologiia. 2003;43(1):44-6.

[Article in Russian]

Authors

E V Shliakhto, E I Shwarts, L A Sokolova, Iu B Nefedova, A V Zhukova, T A Vinnik, I A Tolstova, O G Rudomanov, A O Konradi

PMID: 12891286

Abstract

Aim: To elucidate association of a polymorphic marker C825T of the beta(3)-subunit of G-protein with myocardial hypertrophy in hypertension.

Material and methods: Alleles of polymorphic marker C825T of the CNB3 gene were identified by polymerase chain reaction with subsequent cleavage of the product by BseDI restrictase in 135 patients with hypertensive disease (essential hypertension). Left ventricular mass was determined by echocardiography.

Results: Patients with and without left ventricular hypertrophy had similar frequencies of T allele of the gene studied. Moreover patients with CC, CT and TT genotypes had similar left ventricular mass index (122.3+/-29.8, 118.8+/-29.9, and 115.2+/-18.3 g/m(2), respectively).

Conclusion: No association exists between polymorphic marker C825T of the CNB3 gene and left ventricular hypertrophy in patients with essential hypertension.

Publication types

English Abstract

MeSH terms

Alleles
Female
Genetic Markers
Genotype
Heterotrimeric GTP-Binding Proteins / genetics*
Humans
Hypertension / complications*
Hypertension / diagnosis
Hypertrophy, Left Ventricular / complications*
Hypertrophy, Left Ventricular / diagnosis
Hypertrophy, Left Ventricular / genetics*
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*

Substances

G-protein beta3 subunit
Genetic Markers
Heterotrimeric GTP-Binding Proteins