Synthesis of carbocyclic 1-[4-(hydroxymethyl)cyclopent-2-enyl]-1,2,4-triazole-3-carboxamide and its derivatives

Nucleosides Nucleotides Nucleic Acids. 2003 Apr;22(4):437-51. doi: 10.1081/NCN-120022033.

Abstract

The synthesis of carbocyclic 1-[4-(hydroxymethyl)cyclopent-2-enyl]-1,2,4-triazole-3-carboxamide (6a) and its derivatives was achieved from triol 10 in excellent overall yield. This route involves a Pd(0)-catalyzed coupling reaction as a key step.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids, Carbocyclic / chemistry
  • Antiviral Agents / chemistry*
  • Cyclopentanes / chemical synthesis*
  • Cyclopentanes / chemistry
  • Nucleosides / chemical synthesis*
  • Nucleosides / chemistry
  • Palladium / chemistry
  • Ribavirin / chemistry
  • Triazoles / chemical synthesis*
  • Triazoles / chemistry

Substances

  • Acids, Carbocyclic
  • Antiviral Agents
  • Cyclopentanes
  • Nucleosides
  • Triazoles
  • carbocyclic 1-(4-(hydroxymethyl)cyclopent-2-enyl)-1,2,4-triazole-3-carboxamide
  • 1,2,4-triazole-3-carboxamide
  • Ribavirin
  • Palladium