Abstract
The synthesis of carbocyclic 1-[4-(hydroxymethyl)cyclopent-2-enyl]-1,2,4-triazole-3-carboxamide (6a) and its derivatives was achieved from triol 10 in excellent overall yield. This route involves a Pd(0)-catalyzed coupling reaction as a key step.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids, Carbocyclic / chemistry
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Antiviral Agents / chemistry*
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Cyclopentanes / chemical synthesis*
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Cyclopentanes / chemistry
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Palladium / chemistry
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Ribavirin / chemistry
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Triazoles / chemical synthesis*
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Triazoles / chemistry
Substances
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Acids, Carbocyclic
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Antiviral Agents
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Cyclopentanes
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Nucleosides
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Triazoles
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carbocyclic 1-(4-(hydroxymethyl)cyclopent-2-enyl)-1,2,4-triazole-3-carboxamide
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1,2,4-triazole-3-carboxamide
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Ribavirin
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Palladium