Role of MAP kinase in tumor progression and invasion

Kaladhar B Reddy; Sanaa M Nabha; Natasha Atanaskova

doi:10.1023/a:1023781114568

Role of MAP kinase in tumor progression and invasion

Cancer Metastasis Rev. 2003 Dec;22(4):395-403. doi: 10.1023/a:1023781114568.

Authors

Kaladhar B Reddy¹, Sanaa M Nabha, Natasha Atanaskova

Affiliation

¹ Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA. kreddy@med.wayne.edu

PMID: 12884914
DOI: 10.1023/a:1023781114568

Abstract

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Apoptosis
Cell Movement
Disease Progression
Humans
MAP Kinase Signaling System*
Models, Biological
Neoplasm Invasiveness
Neoplasms / enzymology
Neoplasms / pathology*
Neovascularization, Pathologic
Signal Transduction

Grants and funding

R01 CA 83964/CA/NCI NIH HHS/United States