Acetophenone derivatives from Acronychia pedunculata

J Nat Prod. 2003 Jul;66(7):990-3. doi: 10.1021/np030054x.

Abstract

Chemical investigation on the stem and root bark of Acronychia pedunculata has resulted in the isolation of five new acetophenones, namely, acronyculatins A (1), B (2), C (3), D (4), and E (5). The structures of these metabolites were established on the basis of their 1D and 2D NMR spectroscopic and mass spectrometric data and by CD spectroscopy. The antioxidant and antityrosinase activities of these five metabolites and acrovestone (6) were evaluated. Among these compounds, 6 showed marginal antioxidant and antityrosinase activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetophenones / chemistry
  • Acetophenones / isolation & purification*
  • Acetophenones / pharmacology
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology
  • Circular Dichroism
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Inhibitory Concentration 50
  • Molecular Structure
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Bark / chemistry
  • Plants, Medicinal / chemistry*
  • Rutaceae / chemistry*
  • Taiwan

Substances

  • Acetophenones
  • Antioxidants
  • Enzyme Inhibitors
  • acrovestone
  • Monophenol Monooxygenase