Abstract
The aerial parts of Mikania thapsoides afforded six new cis,cis-germacranolide-type sesquiterpene lactones (1-6), of which three (1-3) have an unusual 3,4-epoxy function, and also afforded two new melampolides (7 and 8). All compounds have a trans C-8 lactone ring closure. Their structures were elucidated using 1D and 2D NMR measurements, and the absolute configuration of 1 was determined using the Mosher ester method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Argentina
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Cyclization
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Lactones / chemistry*
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Lactones / isolation & purification*
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Mikania / chemistry*
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Sesquiterpenes, Germacrane / chemistry*
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Sesquiterpenes, Germacrane / isolation & purification*
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Stereoisomerism
Substances
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Lactones
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Sesquiterpenes, Germacrane