Abstract
The saponin fraction from the flower buds of Panax notoginseng exhibited protective effect on liver injury induced by d-galactosamine and lipopolysaccharide. From the saponin fraction with hepatoprotective effect, five new dammarane-type triterpene saponins, notoginsenosides-O (1), -P (2), -Q (3), -S (4), and -T (5), were isolated together with nine known protopanaxadiol oligoglycosides. The structures of the new saponins were elucidated on the basis of chemical and physicochemical evidence. The principal dammarane-type triterpene saponins from the roots and flower buds of Panax notoginseng were found to show potent hepatoprotective effects.
MeSH terms
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Animals
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Dammaranes
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Flowers / chemistry
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Galactosamine / pharmacology
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Lipopolysaccharides / pharmacology
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Liver / drug effects
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Male
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Mice
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Panax / chemistry*
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Plants, Medicinal / chemistry*
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Salmonella enteritidis / chemistry
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Drugs, Chinese Herbal
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Lipopolysaccharides
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Saponins
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Triterpenes
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Galactosamine