Identification of harman as the antibiotic compound produced by a tunicate-associated bacterium

H Aassila; M L Bourguet-Kondracki; S Rifai; A Fassouane; M Guyot

doi:10.1007/s10126-002-0060-7

Identification of harman as the antibiotic compound produced by a tunicate-associated bacterium

Mar Biotechnol (NY). 2003 Mar-Apr;5(2):163-6. doi: 10.1007/s10126-002-0060-7.

Authors

H Aassila¹, M L Bourguet-Kondracki, S Rifai, A Fassouane, M Guyot

Affiliation

¹ Laboratoire de Biochimie Marine, Département de Biologie, Faculté des Sciences, Université Chouaib Doukkali, BP 20 El Jadida, Morocco.

PMID: 12876652
DOI: 10.1007/s10126-002-0060-7

Abstract

The alkaloid harman, previously reported from some marine invertebrates, was identified as the antibiotic substance of the tunicate-associated bacterium Enterococcus faecium. It exhibited antibacterial activity (MIC, 0.017 mM) against the ichthyopathogenic strain Vibrio anguillarum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Enterococcus faecium / isolation & purification
Enterococcus faecium / metabolism*
Harmine / analogs & derivatives*
Harmine / biosynthesis
Harmine / isolation & purification*
Harmine / pharmacology
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects
Urochordata / microbiology*
Vibrio / drug effects

Substances

Anti-Bacterial Agents
Harmine
harman