Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2809-11. doi: 10.1016/s0960-894x(03)00529-8.

Abstract

A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Fibrosarcoma
  • Humans
  • Photochemotherapy
  • Photosensitizing Agents / chemical synthesis*
  • Photosensitizing Agents / pharmacology
  • Pyrroles / chemistry*
  • Quinolones / chemical synthesis*
  • Quinolones / pharmacology
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Photosensitizing Agents
  • Pyrroles
  • Quinolones