The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: non-taxane derived mimics of taxol?

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2693-7. doi: 10.1016/s0960-894x(03)00543-2.

Abstract

In the course of our investigation into the use of taxol as a lead compound to design new molecules with anti-cancer activity, we have synthesized four compounds based on protected guanosine coupled to taxol isoserine side-chain analogues. These analogues show in vitro anti-cancer activity against the colon cancer cell line SW480 that their constituent parts do not.

Publication types

  • Comparative Study

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemical synthesis*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Bridged-Ring Compounds
  • Cell Line, Tumor / drug effects
  • Colonic Neoplasms
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Guanosine / analogs & derivatives*
  • Humans
  • Microtubules / drug effects
  • Paclitaxel / analogs & derivatives*
  • Structure-Activity Relationship
  • Taxoids

Substances

  • Antineoplastic Agents, Phytogenic
  • Bridged-Ring Compounds
  • Taxoids
  • Guanosine
  • taxane
  • Paclitaxel