Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties

Yong-Pil Kim; Hiroshi Tomoda; Kousuke Iizima; Takashi Fukuda; Atsuko Matsumoto; Yoko Takahashi; Satoshi Omura

doi:10.7164/antibiotics.56.448

Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties

J Antibiot (Tokyo). 2003 May;56(5):448-53. doi: 10.7164/antibiotics.56.448.

Authors

Yong-Pil Kim¹, Hiroshi Tomoda, Kousuke Iizima, Takashi Fukuda, Atsuko Matsumoto, Yoko Takahashi, Satoshi Omura

Affiliation

¹ Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

PMID: 12870809
DOI: 10.7164/antibiotics.56.448

Abstract

Three new pentaene macrolides having a 28-membered ring, designated takanawaenes A, B and C, were isolated from the fermentation broth of Streptomyces sp. K99-5278 by solvent extraction, silica-gel column chromatography and HPLC. Takanawaenes showed antifungal activity against Aspergillus niger, Mucor racemosus, Candida albicans and Saccharomyces cerevisiae.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Fermentation
Lactones / isolation & purification*
Lactones / pharmacology
Polyenes / isolation & purification*
Polyenes / pharmacology
Streptomyces / classification*
Streptomyces / metabolism

Substances

Antifungal Agents
Lactones
Polyenes
takanawaene A
takanawaene B
takanawaene C