Abstract
In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus away from the large subunit in the cytoplasm.
MeSH terms
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COP9 Signalosome Complex
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Cell Cycle / physiology*
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Cullin Proteins / metabolism
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Models, Biological*
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Multiprotein Complexes
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Peptide Hydrolases
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Proteins / genetics*
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Proteins / metabolism
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Ribonucleotide Reductases / metabolism*
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Schizosaccharomyces
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Ubiquitin-Protein Ligases / metabolism
Substances
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Cullin Proteins
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Multiprotein Complexes
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Proteins
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Ribonucleotide Reductases
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Ubiquitin-Protein Ligases
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Peptide Hydrolases
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COP9 Signalosome Complex