COP9 signalosome: a provider of DNA building blocks

Curr Biol. 2003 Jul 15;13(14):R565-7. doi: 10.1016/s0960-9822(03)00475-5.

Abstract

In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus away from the large subunit in the cytoplasm.

Publication types

  • Review

MeSH terms

  • COP9 Signalosome Complex
  • Cell Cycle / physiology*
  • Cullin Proteins / metabolism
  • Models, Biological*
  • Multiprotein Complexes
  • Peptide Hydrolases
  • Proteins / genetics*
  • Proteins / metabolism
  • Ribonucleotide Reductases / metabolism*
  • Schizosaccharomyces
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • Cullin Proteins
  • Multiprotein Complexes
  • Proteins
  • Ribonucleotide Reductases
  • Ubiquitin-Protein Ligases
  • Peptide Hydrolases
  • COP9 Signalosome Complex