In a clinical multicenter observational study including 584 women attended by 99 participating gynaecologists the quality of life changes after 3 month use of an oral contraceptive preparation containing 30 mcg ethinylestradiol (EE) and 3 mg drospirenone was evaluated through the use of a self developed questionnaire using 20 items with a 5 scale answer scheme. We found a mean positive change of life quality of 7.3%. Significant changes were observed regarding subjective experiences of weight, skin, hair, cycle, attractivity, libido and mental wellbeing.