G-CSF mobilised progenitor cells in autologous transplantation: in vitro and in vivo aspects

J Nutr Sci Vitaminol (Tokyo). 1992:Spec No:368-71. doi: 10.3177/jnsv.38.special_368.

Abstract

G-CSF administration leads to significant elevation in the levels of circulating progenitor cells. Infusion of these cells after high-dose chemotherapy is associated with accelerated platelet engraftment that has a considerable impact in shortening thrombocytopenia and reducing need for platelet transfusions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antineoplastic Agents / adverse effects*
  • Blood Component Transfusion / methods*
  • Bone Marrow Transplantation / adverse effects*
  • Cells, Cultured
  • Colony-Forming Units Assay
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • Hematopoietic Stem Cells / drug effects*
  • Humans
  • Middle Aged
  • Risk Factors
  • Thrombocytopenia / drug therapy
  • Transplantation, Autologous

Substances

  • Antineoplastic Agents
  • Granulocyte Colony-Stimulating Factor