Abstract
Regulation of cytoskeletal dynamics is required to coordinate cell movement, adhesion and shape change. The Ena/VASP protein family is thought to play an important role in linking signaling pathways to remodeling of the actin cytoskeleton. This review will examine the mechanisms by which Ena/VASP function might control actin dynamics and how these proteins are linked to various signaling pathways.
MeSH terms
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Actin Cytoskeleton / metabolism*
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Animals
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Cell Adhesion / physiology*
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Cell Adhesion Molecules / metabolism*
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Cell Movement / physiology*
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Cell Size / physiology
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DNA-Binding Proteins / metabolism*
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Eukaryotic Cells / metabolism*
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Eukaryotic Cells / ultrastructure
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Humans
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Microfilament Proteins
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Phosphoproteins / metabolism*
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Pseudopodia / metabolism
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Pseudopodia / ultrastructure
Substances
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Cell Adhesion Molecules
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DNA-Binding Proteins
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ENA-VASP proteins
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Microfilament Proteins
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Phosphoproteins
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vasodilator-stimulated phosphoprotein