Function and regulation of Ena/VASP proteins

Trends Cell Biol. 2003 Jul;13(7):386-92. doi: 10.1016/s0962-8924(03)00130-2.

Abstract

Regulation of cytoskeletal dynamics is required to coordinate cell movement, adhesion and shape change. The Ena/VASP protein family is thought to play an important role in linking signaling pathways to remodeling of the actin cytoskeleton. This review will examine the mechanisms by which Ena/VASP function might control actin dynamics and how these proteins are linked to various signaling pathways.

Publication types

  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Animals
  • Cell Adhesion / physiology*
  • Cell Adhesion Molecules / metabolism*
  • Cell Movement / physiology*
  • Cell Size / physiology
  • DNA-Binding Proteins / metabolism*
  • Eukaryotic Cells / metabolism*
  • Eukaryotic Cells / ultrastructure
  • Humans
  • Microfilament Proteins
  • Phosphoproteins / metabolism*
  • Pseudopodia / metabolism
  • Pseudopodia / ultrastructure

Substances

  • Cell Adhesion Molecules
  • DNA-Binding Proteins
  • ENA-VASP proteins
  • Microfilament Proteins
  • Phosphoproteins
  • vasodilator-stimulated phosphoprotein