Abstract
A new cyclic tetrapeptide (1) was isolated from the culture broth of an actinomycete of the genus Nocardiopsis collected from the Pacific deep-sea sediment. The structure of this compound was determined to be cyclo-(L-isoleucyl-L-prolyl-L-leucyl-L-prolyl) on the basis of combined chemical and spectral methods.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinomycetales / chemistry*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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K562 Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pacific Ocean
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
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Stereoisomerism
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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Peptides, Cyclic
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cyclo-(L-isoleucyl-L-prolyl-L-leucyl-L-prolyl)