A new cyclic peptide from a marine-derived bacterium of the genus Nocardiopsis

J Nat Prod. 2003 Jun;66(6):883-4. doi: 10.1021/np030075r.

Abstract

A new cyclic tetrapeptide (1) was isolated from the culture broth of an actinomycete of the genus Nocardiopsis collected from the Pacific deep-sea sediment. The structure of this compound was determined to be cyclo-(L-isoleucyl-L-prolyl-L-leucyl-L-prolyl) on the basis of combined chemical and spectral methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomycetales / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • K562 Cells
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Pacific Ocean
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Stereoisomerism
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • Peptides, Cyclic
  • cyclo-(L-isoleucyl-L-prolyl-L-leucyl-L-prolyl)