Abstract
We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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CD4-Positive T-Lymphocytes / immunology
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Case-Control Studies
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Chi-Square Distribution
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Developing Countries*
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HIV Infections / immunology*
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Humans
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Immunophenotyping
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India
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Interleukin-4 / analysis*
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Interleukin-4 / genetics
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Lipopolysaccharide Receptors / immunology
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Polymorphism, Genetic
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RNA, Messenger / analysis
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Receptors, CCR5 / analysis
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Receptors, CCR5 / genetics
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Receptors, CXCR4 / analysis*
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Receptors, CXCR4 / genetics
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Statistics, Nonparametric
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T-Lymphocytes / immunology*
Substances
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Lipopolysaccharide Receptors
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RNA, Messenger
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Receptors, CCR5
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Receptors, CXCR4
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Interleukin-4