Abstract
Dichloromethane extracts of both the roots and the leaves of Raimondia cf. monoica showed in vitro antiplasmodial and leishmanicidal activities against Plasmodium falciparum and Leishmania panamensis, respectively. Three 6-substituted 5,6-dihydro-2H-pyran-2-ones were isolated. (1) and (2) were identified as (6S)-(5'-oxohepten-1'E,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one (1) and (6R)-(5'-oxohepten-1'Z,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one (2), respectively. (-)-Arentilactone (3) was also isolated. The structure of the new compound (1) was determined by spectroscopic methods; additional spectroscopic data for (2) are reported for the first time.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Annonaceae / chemistry*
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Antiprotozoal Agents / chemistry*
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Antiprotozoal Agents / isolation & purification
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Antiprotozoal Agents / pharmacology*
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Lactones / chemical synthesis*
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Lactones / isolation & purification
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Lactones / pharmacology*
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Leishmania / drug effects
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Molecular Structure
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Plant Leaves / chemistry
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Plant Roots / chemistry
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Plasmodium falciparum / drug effects
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Pyrones / chemical synthesis*
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Pyrones / chemistry*
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Pyrones / isolation & purification
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Pyrones / pharmacology*
Substances
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(6S)-(5'-oxohepten-1'E,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one
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Antiprotozoal Agents
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Lactones
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Pyrones
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arentilactone