Morierinin: a new cytotoxic cucurbitacin from the leaves of Morierina montana Vieill

Nat Prod Res. 2003 Aug;17(4):229-33. doi: 10.1080/1057563021000042329.

Abstract

An extract of the leaves of Morierina montana collected in New Caledonia was found to be cytotoxic for KB cells. A bioassay-guided fractionation procedure led to the isolation of a series of cucurbitacins of which one, morierinin (1), is new. The isolation and structure elucidation of 1 are described.

MeSH terms

  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Leaves / chemistry*
  • Rubiaceae / chemistry*
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification*

Substances

  • Plant Extracts
  • Triterpenes
  • morierinin
  • cucurbitacin B
  • cucurbitacin E
  • 23,24-dihydrocucurbitacin B