Abstract
Among a collection of 4281 pneumococcal isolates, 7 strains isolated in Germany had an unusual macrolide resistance phenotype. The isolates were found to have multiple mutations in the 23S rRNA and alterations in the L4 ribosomal protein. One strain had an amino acid alteration in the L22 ribosomal protein.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Bacterial
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Genotype
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Germany
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Macrolides
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Molecular Sequence Data
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Point Mutation
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RNA, Ribosomal, 23S / genetics*
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Ribosomal Proteins / genetics*
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / genetics*
Substances
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Anti-Bacterial Agents
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Macrolides
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RNA, Ribosomal, 23S
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Ribosomal Proteins
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ribosomal protein L4