Abstract
A case of cutaneous atypical fibroxanthoma (AFX) which metastasized, leading to patient death, is described. This is the third reported case in which a lesion qualified as AFX behaves in such an aggressive manner, comparable with that of malignant fibrous histiocytoma (MFH). Ki-67 proliferation index, p53 and bcl-2 protein expression and DNA ploidy were also consistent with a highly malignant potential. The controversial issue of the biological behavior of AFX and its relationship with MFH is discussed. The authors conclude that MFH and AFX probably represent a single entity with a split biological "personality".
MeSH terms
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Aged
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Diagnosis, Differential
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Histiocytoma, Benign Fibrous / diagnosis
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Histiocytoma, Benign Fibrous / genetics
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Histiocytoma, Benign Fibrous / metabolism
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Histiocytoma, Benign Fibrous / pathology*
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Histiocytoma, Benign Fibrous / secondary
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Humans
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Male
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Ploidies
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Proto-Oncogene Proteins c-bcl-2 / biosynthesis
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Skin Neoplasms / diagnosis
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Skin Neoplasms / genetics
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Skin Neoplasms / metabolism
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Skin Neoplasms / pathology*
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Tumor Suppressor Protein p53 / biosynthesis
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Tumor Suppressor Protein p53 / genetics
Substances
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Proto-Oncogene Proteins c-bcl-2
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Tumor Suppressor Protein p53