Abstract
Introduction:
To compare compliance with two isoniazid regimens in drug users with latent tuberculosis infection. METHODS.
Design:
clinical trial. Group 1: isoniazid 300 mg once daily (16 patients); Group 2: isoniazid 900 mg/twice weekly (21).
Endpoints:
compliance, toxicity and efficacy.
Results:
Group 1 vs. Group 2: continuation in program 81/82% (p 5 NS), compliance full doses 43.7/66.6% (p 5 0.1), median percentage of days not taking isoniazid: 1.8 (0.2-4.3) vs. 0 (0-1.7) (p 5 0.06).
Conclusions:
Compliance was high in both therapeutic arms. The twice-weekly isoniazid regimen favored compliance, but differences were not significant.
Publication types
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Clinical Trial
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Comparative Study
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English Abstract
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / therapeutic use*
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Carrier State / drug therapy*
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Drug Administration Schedule
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Female
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Humans
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Isoniazid / administration & dosage
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Isoniazid / therapeutic use*
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Male
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Methadone / therapeutic use
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Middle Aged
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Patient Compliance
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Substance-Related Disorders / complications
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Substance-Related Disorders / rehabilitation
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Tuberculosis / complications
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Tuberculosis / drug therapy*
Substances
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Antitubercular Agents
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Methadone
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Isoniazid