Abstract
Three new diterpene esters with a myrsinol-type skeleton have been isolated from Euphorbia decipiens BOISS. & BUHSE. The structure elucidation of the isolated compounds was based primarily on two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC) and nuclear Overhauser effect spectroscopy (NOESY) experiments. Compounds 1 and 3 are active against prolyl endopeptidase and compound 2 showed inhibitory activity against urease enzyme.
MeSH terms
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Esters / chemistry
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Esters / isolation & purification*
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Esters / pharmacology
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Euphorbia / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Prolyl Oligopeptidases
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Serine Endopeptidases / metabolism
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Serine Proteinase Inhibitors / chemistry
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Serine Proteinase Inhibitors / isolation & purification
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Serine Proteinase Inhibitors / pharmacology
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Urease / antagonists & inhibitors*
Substances
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Diterpenes
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Enzyme Inhibitors
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Esters
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Plant Extracts
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Serine Proteinase Inhibitors
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Serine Endopeptidases
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Prolyl Oligopeptidases
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Urease