Extracardiac anomalies, aneuploidy and growth retardation in 100 consecutive fetal congenital heart defects

M L Respondek; C N Binotto; S Smith; A Donnenfeld; S R Weil; J C Huhta

doi:10.1046/j.1469-0705.1994.04040272.x

Extracardiac anomalies, aneuploidy and growth retardation in 100 consecutive fetal congenital heart defects

Ultrasound Obstet Gynecol. 1994 Jul 1;4(4):272-8. doi: 10.1046/j.1469-0705.1994.04040272.x.

Authors

M L Respondek¹, C N Binotto, S Smith, A Donnenfeld, S R Weil, J C Huhta

Affiliation

¹ Pennsylvania Hospital, Philadelphia 19107, USA.

PMID: 12797160
DOI: 10.1046/j.1469-0705.1994.04040272.x

Abstract

The importance of extracardiac anomalies in 100 consecutive fetuses with congenital heart disease was evaluated. The most common cardiac diagnoses were hypoplastic left heart syndrome in 35% and atrioventricular canal defect in 15%. Extracardiac anomalies were present in 42%, abnormal karyotype in 19% and intrauterine growth retardation in 20%. There were 45 survivors (35 required neonatal surgery, ten did not require early surgery) and 80% (36/45) of the survivors had isolated congenital heart disease. Extracardiac anomalies and abnormal karyotype were more frequently present in non-survivors (p < 0.001). Also, intrauterine growth retardation was more frequent in non-survivors (p < 0.05).