The title complex, bis(acetylacetonato-kappa(2)O,O')[N,N'-bis(3-hydroxy-2-oxidobenzaldimino)-2-methyl-1,2-propanediamine-kappa(4)N,O,O',N']uranium(IV) tetrahydrofuran solvate, [U(C(18)H(18)N(2)O(4))(C(5)H(7)O(2))(2)].C(4)H(8)O, is a rare example of a uranium(IV) complex with a compartmental Schiff base. The U atom is located in the N(2)O(2) inner site of the hexadentate N,N'-bis(3-hydroxy-2-oxidobenzaldimino)-2-methyl-1,2-propanediamine group and is bound also to the two O atoms of both acetylacetonate moieties, which results in a dodecahedral coordination environment. Centrosymmetric dimers are formed through intermolecular hydrogen bonds that link the terminal uncoordinated hydroxy groups to one another and to the O atoms of the acetylacetonate ligands.