Microwave-assisted synthesis of diaryl ethers without catalyst

Org Lett. 2003 Jun 12;5(12):2169-71. doi: 10.1021/ol0346436.

Abstract

[reaction: see text] Diaryl ethers have been prepared by direct coupling of phenols including those that bear a strong electron-attracting substituent to electron-deficient aryl halides through S(N)Ar-based addition reactions with assistance of microwave irradiation in high to excellent yields within 5-10 min. No catalysts were required under our conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hydrocarbons, Aromatic / chemical synthesis*
  • Hydrocarbons, Aromatic / chemistry
  • Microwaves
  • Phenols / chemistry*
  • Phenyl Ethers / chemical synthesis*

Substances

  • Hydrocarbons, Aromatic
  • Phenols
  • Phenyl Ethers